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Venlafaxine -0.1 mg/kg Sertraline was used to control an increase in serotonin and dopamine levels. Sertraline increased the serotonin levels but had little effect on dopamine. The authors did find that levels of a serotonergic receptor were significantly increased. There was an increase in extracellular concentrations of dopamine. They suggest that the serotonin-to-cascade hypothesis is correct. authors concluded that in schizophrenia, serotonin is the neurotransmitter in question. data were interpreted as suggesting that the symptoms of disorder are not simply the result of increased dopamine or serotonin levels. A recent article (2009) suggests that a decrease in serotonin levels can explain the worsening in psychotic symptoms schizophrenia. A decrease in serotonin levels is known to cause schizophrenia symptoms. A previous study found an increase in dopamine levels the prefrontal cortex of schizophrenic patients (2005). This study used PET to measure and quantitate serotonin levels, dopamine levels and Rosuvastatin 10mg $162.94 - $1.81 Per pill of neurofibrillary tangles. The results suggested that serotonin deficits are related to the severity and degree of psychotic symptoms. The authors argue that low serotonin can cause psychosis and that this is most likely a cause of the increased psychotic symptoms. They suggest that the serotonin to dopamine hypothesis is correct and that the disorder may be related with the serotonin-to-cascade theory. They also suggest that there are several different pathways that serotonin can take in the brain: 1) 5HT neurons (serotonin transporters, etc), 2) 5HT 1 receptors and 3) the 5-HIAA pathway. All these processes will be reviewed later.
Sertraline has not been approved for use in humans; however, this compound has shown promise in animal models of schizophrenia and depression. One study (2007) compared the efficacy of Sertraline, Risperdal and Fluoxetine, compared to placebo, on the change in Hamilton Depression Rating Scale
Finasteride cheapest price (HAM-D) scores over a 14 week treatment period in patients with first-episode schizophrenia. Sertraline reduced the HAM-D scores by 9 points and Risperdal 5 points, Fluoxetine by 7 points. Both treatment with Sertraline and Fluoxetine reduced the total number of HAM-D points, but Sertraline also slightly improved the number of HAM-D positive symptoms. These data suggest that Sertraline might be beneficial and that there is some potential for Sertraline in treating schizophrenia. The researchers rosuvastatin 10 mg kaufen concluded, "We can only surmise to the potential of Sertraline treat these patients." The may be most effective with the patients who have high anxiety and negative symptoms.
Another study (2009) compared the efficacy of Sertraline or Seroquel (an SSRI) on the change in HAM-D scores over a period of 1 year. Both drugs significantly reduced the total number of HAM-D points (Sertraline 5 points, Seroquel 3 points) and the HAM-D overall scale (Sertraline 12 points, Seroquel 10 points). Sertraline also had a significant effect on depressive symptoms. These data suggest that the Sertraline may be helpful as an augmenting treatment strategy to improve symptom management. The authors also conclude that one of the reasons Sertraline may be a treatment choice is because of it's low cost. Sertraline is an alternative to many of those other medications (like Zyprexa) that have a high cost and that have limited effect in treating a very large group of patients. Sertraline is also a good option for those that are not willing or